Strangers no more: Uterine NK cell recognition of the placenta in mice

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Strangers no more: uterine NK cell recognition of the placenta in mice.

S uccessful pregnancy requires a series of coordinated interactions between the developing placenta, the uterus, and the maternal immune system (1). At the maternal/fetal interface, where the placenta contacts the uterus, a specialized type of lymphocyte known as a uterine natural killer (uNK) cell is thought to play a critical role in mediating the uterine vascular adaptations to pregnancy. Ep...

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Placenta growth factor (PlGF; formerly PGF), a vascular endothelial growth factor gene family member, is expressed in human implantation sites by maternal uterine NK (uNK) and fetal trophoblast cells. Lower than normal concentrations of blood and urinary PlGF have been associated with impending onset of pre-eclampsia, a hypertensive disease of late human gestation characterized by limited intra...

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Shape and Type of Uterine Contractions at Premature Detachment: Uterine Behavior Abruption Placenta

Although premature separation of normally implanted placenta is considered the most serious complication of pregnancy, knowledge of uterine behaviour during this con­dition is meager, on the basis of electronic recording of intra-uterine pressure two type of contraction pattern has been identified.  In type I uterine tonus has values below 30mmHg  with a frequency of 4-9 contractions per 10 m...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 2011

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.1101509108